- Tetraspanin Immunology -

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Antigen-presenting cells (APC) like macrophages, B cells and dendritic cells play a key role in anti-tumor immunity by their potent capacity to activate T cells. There is compelling evidence that in particular the spatial organization of immunoreceptors in the plasma membrane of APC is crucial for proper T cell activation and -thus- determines the outcome of the anti-tumor response. Tetraspanin proteins coordinate the spatial organization of specific immunoreceptors and signaling molecules into 'tetraspanin microdomains'. We discovered that tetraspanins are critically involved in APC function, including antigen presentation, proliferation and antibody production. The aim of our research is to unravel the molecular mechanisms that underlie tetraspanin microdomain function in immune cells in relation to the development of malignant disease.

Further reading:

  1. CM de Winde, S Veenbergen, KH Young, Z Xu-Monette, X Wang, Y Xia, K Jabbar, M van den Brand M, A van der Schaaf, S Elfrink, I van Houdt, M Gijbels, F van de Loo, M Bennink, K Hebeda, P Groenen, JH van Krieken, CG Figdor, AB van Spriel. Tetraspanin CD37 protects against the development of B cell lymphoma. J Clin Invest 2016; 126:653.
  2. M Zuidscherwoude, F Göttfert, VM Dunlock, CG Figdor, G van den Bogaart, AB van Spriel. The tetraspanin web revisited by super-resolution microscopy. Sci Rep. 2015; 5:12201.
  3. AB van Spriel, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD. The tetraspanin CD37 orchestrates the a4b1 Integrin-akt signalling axis and supports long-lived plasma cell survival. Science Signaling 2012; 13:5(250):ra82
  4. CG Figdor, AB van Spriel. Fungal pattern-recognition receptors and Tetraspanins; Partners on antigen-presenting cells. Trends Immunol. 2010; 31:91.
  5. AB van Spriel, M Sofi, K Gartlan, A van der Schaaf, I Verschueren, R Torensma, R Raymakers, B Loveland, M Netea, G Adema, M Wright, C Figdor. Tetraspanin CD37 regulates IgA responses and anti-fungal immunity. PLoS Pathog. 2009; 5(3):e1000338.

Contact: Annemiek.vanSpriel@radboudumc.nl