Targeting of dendritic cells in vivo by exploiting an poly (lactic- glycolic acid) PLGA nano bead platform to develop new synthetic vaccines and a program to develop synthetic Dendritic Cells to directly activate T cells
The plasma membrane of immune cells is highly organized. Immune cell function, including antigen presentation and antibody production, is tightly regulated by tetraspanin membrane proteins that couple to intracellular signaling pathways.
Dendritic Cell (DC) therapy represents a promising immunotherapeutic approach for the treatment of cancer. The beauty of DC therapy is that it exploits the body's own immune system to fight cancer.
The ultimate aim of the Membrane Trafficking in Immune Cells Group (www.membranetrafficking.com) is to understand the intracellular membrane trafficking cascades by which dendritic cells initiate a naive T cell response.
The tumor microenvironment and how one could reverse immunosupression.
Research within the Multiscale Imaging group focuses on new types of contrast agents for multiple types of imaging such as 1H and 19F magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), single photon emission CT (SPECT), bioluminescence, ultrasound, optoacoustics and fluorescence, simultaneously.