Research

Chemical Immunology

PLGA platform 207_128

Targeting of dendritic cells in vivo by exploiting an poly (lactic- glycolic acid) PLGA nano bead platform to develop new synthetic vaccines and a program to develop synthetic Dendritic Cells to directly activate T cells

Immune cell signaling

Tetraspanin 207x128

The plasma membrane of immune cells is highly organized. Immune cell function, including antigen presentation and antibody production, is tightly regulated by tetraspanin membrane proteins that couple to intracellular signaling pathways.

DC Vaccination

cleanroom207x128.jpg

Dendritic Cell (DC) therapy represents a promising immunotherapeutic approach for the treatment of cancer. The beauty of DC therapy is that it exploits the body's own immune system to fight cancer.

 

Membrane Trafficking

Membrane Trafficking 207x128

The ultimate aim of the Membrane Trafficking in Immune Cells Group (www.membranetrafficking.com) is to understand the intracellular membrane trafficking cascades by which dendritic cells initiate a naive T cell response.

Tumor Microenvironment

3D skin

The tumor microenvironment and how one could reverse immunosupression.