Geert van den Bogaart

Geert van den Bogaart

Bogaart Geert vd

Profile

Geert van den Bogaart is a biochemist and cell biologist studying intracellular membrane trafficking. Research interests include the molecular mechanisms controlling cytokine release and the processing of antigen by antigen presenting cells, in particular dendritic cells. Geert’s group also develops new tools to study intracellular membrane trafficking pathways. More information can be found on the homepage of his laboratory: www.membranetrafficking.com

Short CV

After obtaining his PhD in biochemistry with distinction (2008, University of Groningen, the Netherlands), Geert van den Bogaart worked as a postdoctoral fellow in neurobiology at the Max Planck Institute for Biophysical Chemistry (2008-2012, Göttingen, Germany). In 2012, Geert started his own group at the department of Tumor Immunology (Radboud University Medical Center, Nijmegen) funded by a Hypatia tenure track fellowship. His group, the Membrane Trafficking in Immune Cells Laboratory, studies membrane trafficking in immune cells. Geert is the recipient of the Dutch Society Prize for Young Talent (2004), the H.G.K.Westenbrink Prize (2009), the Heineken Young Scientist Award for Biochemistry and Biophysics (2012), a Hypathia Tenure Track Grant from the Radboud University Medical Center (2912), a Starting Grant from the European Research Council (2012), a Career Development Award from the Human Frontier Science Program (2013) and a VIDI grant from the Netherlands Organisation for Scientific Research (2015).

 Key words
Tumor immunology, membrane trafficking, dendritic cells, exocytosis, endocytosis, phagocytosis.

 Break-through discoveries

  1. Finding a novel way how dendritic cells (DCs) sample for pathogens through barriers such as epithelium from lung, gut and intestine. J. Cell. Sci. 2014.
  2. Finding a novel mechanism how electrostatic interactions between polyanionic phosphoninositides and membrane proteins can lead to membrane domain formation. Nature 2011.
  3. Finding that a single SNARE complex suffices for membrane fusion. Nature Struct. Mol. Biol. 2009.

Topics

Membrane trafficking mechanisms underlying T cell activation. Polarized trafficking of cytokines and membrane receptors to the immunological synapse between dendritic cells and T cells. The molecular pathways of cytokine secretion. The molecular mechanisms for the uptake and subsequent degradation of foreign antigen by dendritic cells. The antigen-specific maturation steps of endosomes and phagosomes. The assembly of the NADPH-oxidase NOX2 on antigen containing compartments The rerouting of intracellular membrane trafficking pathways upon antigen recognition by dendritic cells.

Recent key publications

See www.membranetrafficking.com for the complete list.

  • Milovanovic, D., Honigmann, A., Koike, S., Göttfert, F., Pähler, G., Junius, M, Müllar, S., Diederichsen, U., Janshoff, A., Grubmüller, H., Risselada, H.J., Eggeling, C., Hell, S.W., van den Bogaart, G., & Jahn, R. (2015) Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains. Nat. Commun. 6: 5984.
  • Baranov, M.V., Ter Beest, M., Reinieren-Beeren, I., Cambi, A., Figdor, C.G. & van den Bogaart, G. (2014) Podosomes of dendritic cells facilitate antigen sampling. J. Cell Sci. 127: 1052-1064.
  • Honigmann, A., van den Bogaart, G., Iraheta, E., Risselada, H.J., Milovanovic, D., Mueller, V., Muellar, S., Diederichsen, U., Fasshauer, D., Grubmüller, H., Hell, S.W., Eggeling, C., Kühnel, K. & Jahn, R. (2013) Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat. Struct. Mol. Biol. 20: 679-686.
  • van den Bogaart, G., Meyenberg, K., Risselada, H.J., Amin, H., Willig, K.I., Hubrich, B.E., Dier, M., Hell, S.W., Grubmüller, H., Diederichsen, U. & Jahn, R. (2011) Membrane protein sequestering by ionic protein-lipid interactions. Nature 479: 552-555.
  • van den Bogaart, G., Thutupalli, S., Risselada, J.H., Meyenberg, K., Holt, M., Riedel, D., Diederichsen, U., Herminghaus, S., Grubmüller, H. & Jahn, R. (2011) Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat. Struct. Mol. Biol. 18: 805-812.