Annemiek van Spriel

Annemiek van Spriel

Spriel Annemiek Van

Member management team

 

Profile

Scientific interests include immunology at the cellular and molecular level with a major focus on the plasma membrane organization of antigen-presenting cells. The plasma membrane is essential for immune cell function due to its unique role in the communication between the inside and outside of the cell, and the initiation of signal transduction pathways. Tetraspanin proteins coordinate the spatial organization of specific immunoreceptors and signaling molecules into ‘tetraspanin microdomains'. We discovered that tetraspanins are critically involved in immune cell function, including antigen presentation, proliferation and antibody production. The aim of our research is to unravel the molecular mechanisms that underlie tetraspanin microdomain function and signaling in immune cells in relation to the development of malignant disease.

Short CV

Annemiek van Spriel obtained her Master’s degree in 1996 from the University of Utrecht (cum laude) and her PhD degree in immunology in 2001 from the University of Utrecht. She pursued a long-term Post-Doctoral Fellowship in the Leukocyte Membrane Laboratory of Ass. Prof. Mark Wright (Burnet Institute, Melbourne, Australia). In 2004, she joined the Tumor Immunology Department in the Radboud Institute for Molecular Life Sciences (RIMLS), and started her own research line focused on investigating tetraspanins in immune cells in relation to the development of cancer. She obtained several Grants from The Netherlands Organization for Scientific Research (NWO) and the Dutch Cancer Society (KWF). In 2012, she organized the 5th European Conference on Tetraspanins in Nijmegen. She has been awarded the prestigious NWO-VIDI and Aspasia Grants in 2012 for her work on tetraspanin proteins in the immune system. Annemiek van Spriel is a tenured faculty member at the Department of Tumor Immunology and chair of the Dutch Society for Immunology (NVVI) Lunteren Symposium committee.

Breakthrough discoveries

  1. Discovery that absence of tetraspanin CD37 leads to spontaneous formation of B cell lymphoma and predicts clinical outcome in patients (Journal Clinical Investigation 2016)
  2. New model of the tetraspanin web on immune cells visualized by super-resolution imaging (Scientific Reports 2015)
  3. Finding that tetraspanin CD37 is essential for optimal B cell responses (Plos Pathogens 2009, Science Signaling 2012)
  4. Identification of cross-talk between Fc receptors and complement receptors that affects neutrophil function (Nature Medicine 2000, Blood 2001, Blood 2003)

 Key publications

  1. CM de Winde, S Veenbergen, KH Young, Z Xu-Monette, X Wang, Y Xia, K Jabbar, M van den Brand M, A van der Schaaf, S Elfrink, I van Houdt, M Gijbels, F van de Loo, M Bennink, K Hebeda, P Groenen, JH van Krieken, CG Figdor, AB van Spriel. Tetraspanin CD37 protects against the development of B cell lymphoma. J Clin Invest 2016; 126:653.
  2. M Zuidscherwoude, F Göttfert, VM Dunlock, CG Figdor, G van den Bogaart, AB van Spriel. The tetraspanin web revisited by super-resolution microscopy. Sci Rep. 2015; 5:12201.
  3. AB van Spriel, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD. The tetraspanin CD37 orchestrates the a4b1 Integrin-akt signalling axis and supports long-lived plasma cell survival. Sci. Signal. 2012; 13:5(250):ra82
  4. CG Figdor, AB van Spriel. Fungal pattern-recognition receptors and Tetraspanins; Partners on antigen-presenting cells. Trends Immunol. 2010; 31:91.
  5. AB van Spriel, M Sofi, K Gartlan, A van der Schaaf, I Verschueren, R Torensma, R Raymakers, B Loveland, M Netea, G Adema, M Wright, C Figdor. Tetraspanin CD37 regulates IgA responses and anti-fungal immunity. PLoS Pathog. 2009; 5(3):e1000338.