Publication in Science Signaling for Malou Zuidscherwoude and Vera Dunlock

Publication in Science Signaling

The underlying molecular mechanisms of PKC signaling in B cells are only partially resolved. Malou Zuidscherwoude and Vera Dunlock, group of Annemiek van Spriel, now discovered that in response to B cell receptor stimulation, PKCb was specifically recruited to plasma membrane microdomains containing tetraspanin CD53. Mouse or human B cells deficient in CD53 showed impaired PKCb activation and reduced phosphorylation of its targets, indicating that tetraspanin microdomains act as signaling platforms for the activation of PKC in B cells.