Publication in Blood on CD37 mutations in lymphoma

Suraya Elfrink, together with Lotte de Winde and Michiel van den Brand, in Annemiek van Spriel's research group Immune cell signaling, theme Cancer development and immune defense, published a manuscript in Blood reporting that tetraspanin CD37 is frequently mutated in patients with diffuse large B cell lymphoma occurring at immune-privileged sites.

The CD37-mutated lymphoma B-cells show impaired CD37 cell surface localization, which has important implications for anti-CD37 immunotherapy.